Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

Abstract excerpt

Biological age, distinct from an individual’s chronological age, has been studied extensively through predictive aging clocks. However, these clocks have limited accuracy in short time-scales. Deep learning approaches on imaging datasets of the eye have proven powerful for a variety of quantitative phenotype inference tasks and provide an opportunity to explore organismal aging and tissue health. Here we trained d...

Topics

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• Aged
• Aging
• Blood Pressure and Hypertension Studies
• Deep Learning
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Retinal Diseases and Treatments
• Retinal Imaging and Analysis

Identifiers and source

Literature Corpus work

ee2acadc-2b7b-5b54-967d-2b64cf1ddf5e

DOI

10.1101/2022.07.25.501485