Article

REECAP: Contrastive learning of retinal aging reveals genetic loci linking morphology to eye disease

2025-11-20

Abstract excerpt

Deep learning foundation models excel at disease prediction from medical images, yet their potential to bridge tissue morphology with the genetic architecture of disease remains underexplored. Here, we present REECAP (Representation learning for Eye Embedding Contrastive Age Phenotypes), a framework that fine-tunes the RETFound retinal foundation model using a contrastive objective guided by chronological age. App...

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Literature Corpus work: ae3ea42b-3dfa-59c8-875b-2a157ffa992d
DOI: 10.1101/2025.11.19.25340555

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