Article
Genomic determinants of biological age estimated by deep learning applied to retinal images.
GeroScience - 1 Apr 2025
Huang Yu, Syed Mohammad Ghouse, Chen Ruiye, Li Cong, Shang Xianwen, Wang Wei, Zhang Xueli, Zhang Xiayin, Tang Shulin, Liu Jing, Liu Shunming, Srinivasan Sundar, Hu Yijun, Mookiah Muthu Rama Krishnan, Wang Huan, Trucco Emanuele, Yu Honghua, Palmer Colin, Zhu Zhuoting, Doney Alexander S F, He Mingguang
Abstract excerpt
With the development of deep learning (DL) techniques, there has been a successful application of this approach to determine biological age from latent information contained in retinal images. Retinal age gap (RAG) defined as the difference between chronological age and predicted retinal age has been established previously to predict the age-related disease. In this study, we performed discovery genome-wide...
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