Article

Deep-learning-enabled morphodynamic analysis of drug responses in a biomimetic fibrin-based 3D glioblastoma invasion model

2026-03-26

Abstract excerpt

Glioblastoma (GBM) lethality arises from aggressive invasion and diffuse infiltration of brain tissue. Conventional GBM preclinical models often fail to predict clinical therapeutic efficacy because they do not recapitulate the pathological extracellular matrix (ECM) cues that drive tumor invasion. Here, we present an ECM mimetic 3D platform using a fibrin scaffold to recapitulate the hemorrhagic, pro-thrombotic t...

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Literature Corpus work: eddcf16a-5060-5cf5-8948-fcbcb2fbe47a
DOI: 10.64898/2026.03.24.713307

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