Article

Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA

2025-05-15

Abstract excerpt

Retrotransposon mobilization in germline cells enables the rewriting of genetic information to drive genome innovation, species evolution, and adaptation through the generation of de novo mutations. However, uncontrolled mobilization can cause DNA breaks and genome instability, often leading to sterility. How germ cells balance retrotransposon-induced genome innovation with the need for genomic integrity remains p...

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Literature Corpus work: edd9e35c-2e4d-501f-baee-b6aba55c8e43
DOI: 10.1101/2025.05.11.653319

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