Formation, persistence, and breakdown of carrier-set topology in linkage disequilibrium: empirical structure in 1000 Genomes and a two-locus Wright–Fisher model

Abstract excerpt

Linkage disequilibrium between two biallelic loci is usually summarized by scalar association measures such as r 2 and D ′ . These measures quantify how visible an allelic association is to a symmetric LD scan, but they do not directly represent the topology of carrier sets: whether the carriers of one variant are contained within, partially overlap with, or are disjoint from the carriers of the other. This dist...

Topics

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• Algorithms
• Chromosome Mapping
• Computer Graphics
• Computer Simulation
• Disease
• Genome-Wide Association Study
• Haplotypes
• Oligonucleotide Array Sequence Analysis

Identifiers and source

Literature Corpus work

edd1b366-0132-57fe-8d67-6accabfe677d

DOI

10.64898/2026.07.01.735767