Article

Deregulation in binding and expression of RNA binding proteins as a mechanism of CD19-negative B-ALL

2022-05-23

Abstract excerpt

<title>Abstract</title> <p>Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the <italic>CD19</italic> locus and aberrant splicing events are known to account for the absence of surface antigen. However, the molecular determinants are not fully enlightened so far. We applied deep seque...

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Literature Corpus work: edcdd875-946a-5a21-b870-78ef87bacb50
DOI: 10.21203/rs.3.rs-1630084/v1

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