Article

Age and Generation-Based Model of Metastatic Cancer: From Micrometastases to Macrometastases

2025-06-30

Abstract excerpt

Metastasis remains the decisive event in most solid cancers, yet the mathematical tools we use to describe it are still largely tied to tumor size. In the curent work, we recast metastatic spread in terms of tumor age and generational ancestry, turning an implicit notion into the main organizing principle of the model. Building on the classical Iwata–Kawasaki–Shigesada (IKS) framework, we construct a transformatio...

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Literature Corpus work: edbe0a8f-5758-55cb-b5a6-fc72ecfe6464
DOI: 10.1101/2025.06.26.661673

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