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Article

Systemic Cancer Progression and Tumor Dormancy: Mathematical Models Meet Single Cell Genomics

2 Aug 2006

Abstract excerpt

Metastatic progression is thought to result from genetically advanced "fully-malignant" tumor cells. Within the concept the prevailing view holds that such cells disseminate mostly from large tumors and are capable of growing into metastases once they arrive at a distant site. Support for this scenario comes from numerous mouse models in which transplanted tumor cells grow into metastases within days or weeks....

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PMID: 16929175
DOI: 10.4161/cc.5.16.3097

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