The CD8⁺T/MDSC ratio: A novel prognostic and predictive biomarker for immunotherapy response in gastric cancer

Abstract excerpt

<title>Abstract</title> <p>Background Immune imbalance in tumor microenvironment is closely linked to GC progression. MDSCs primarily drive immune imbalance by suppressing the anti-tumor activity of CD8⁺T cells. Notably, no prior study has explored the combination of CD8⁺T cells and MDSCs to assess the clinical prognosis or immunotherapy response in GC. Methods PubMed and EMBASE were searched, literature screen...

Topics

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• Cathepsin L
• DNA-Binding Proteins
• Immunologic Factors
• Immunotherapy
• Phenotype
• Stomach Neoplasms
• Transcription Factors
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

edbabb46-2d11-5d5f-85e8-1b3a3c7fd01d

DOI

10.21203/rs.3.rs-9286398/v1