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Clinical Use of ZSCAN4 for Telomere Elongation in Hematopoietic Stem Cells

25 Feb 2025

Abstract excerpt

BACKGROUND: Extremely short telomeres in patients with dyskeratosis congenita and related telomere biology disorders (TBDs) lead to premature cellular senescence and bone marrow failure. Zinc finger and SCAN domain-containing 4 (ZSCAN4) elongates telomeres by recombination. METHODS: at 33°C for 24 hours, was infused into patients without preconditioning. RESULTS: /μl; this has occurred in 5 months without the...

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PMID: 39998303
DOI: 10.1056/evidoa2400252

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