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TaHL-PTM: Post-Translational Modification Prediction in Proteins via Target-Hooked Discriminative Fine-Tuning of Decoder-only Protein Language Models

2026-08-27

Abstract excerpt

Post-translational modifications (PTMs) regulate protein function, making accurate residue-level PTM prediction essential for understanding cellular mechanisms and disease pathways. While decoder-only protein language models (PLMs) pretrained with the causal language modeling (CLM) objective have driven breakthroughs across various bioinformatics tasks, their potential for PTM prediction remains largely underexplo...

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Literature Corpus work: c13c8512-f695-5d60-aea7-83695286d667
DOI: 10.64898/2026.08.24.746791

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