Article

Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production

2022-05-06

Abstract excerpt

The activation of receptor-interacting protein kinase 1 (RIPK1) by death-inducing signaling complex (DISC) formation is essential for triggering the necroptotic mode of cell death under apoptosis-deficient conditions. Thus, targeting the induction of necroptosis by modulating RIPK1 activity could be an effective strategy to bypass apoptosis resistance in certain types of cancer. In this study, we screened a series...

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Literature Corpus work: eda22a3e-cff0-5041-b2d4-5a20d3d5fab5
DOI: 10.21203/rs.3.rs-1616051/v1

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