Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

Abstract excerpt

Apoptosis and autophagy are genetically regulated, evolutionarily conserved processes that can jointly seal the fate of cancer cells. However, substantial gaps remain in our understanding of the molecular mechanisms that mediate the two cellular processes. In the present study, the exposure of murine fibrosarcoma L929 cells to oridonin led to the generation of intracellular reactive oxygen species (ROS) and,...

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