Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.

Cancer letters - 28 Feb 2011

Li Binghui, Zhao Jiong, Wang Chong-Zhi, Searle Jennifer, He Tong-Chuan, Yuan Chun-Su, Du Wei

Abstract excerpt

Ginsenosides are the main bioactive components in American ginseng, a commonly used herb. In this study, we showed that the ginsenoside Rh2 exhibited significantly more potent cell death activity than the ginsenoside Rg3 in HCT116 and SW480 colorectal cancer cells. Cell death induced by Rh2 is mediated in part by the caspase-dependent apoptosis and in part by the caspase-independent paraptosis, a type of cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Amino Acid Chloromethyl Ketones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase Inhibitors

Share to Caspases

Share to Cysteine Proteinase Inhibitors

Share to Drugs, Chinese Herbal

Share to Free Radical Scavengers

Share to HCT116 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21194832
DOI: 10.1016/j.canlet.2010.11.015
PMCID: PMC3022099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.PMID 21194832Read ↗

Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancerSemantic proximity Read ↗

Rhein Inhibits the Growth and Induces the Apoptosis of Hep G2 CellsSemantic proximity Read ↗

Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS productionSemantic proximity Read ↗

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells.Semantic proximity Read ↗

Rhein induces liver cancer cells apoptosis via activating ROS-dependent JNK/Jun/caspase-3 signaling pathwaySemantic proximity Read ↗

Gossypin induces apoptosis and autophagy via the MAPK/JNK pathway in HT‑29 human colorectal cancer cellsSemantic proximity Read ↗

Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.Semantic proximity Read ↗

Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivoSemantic proximity Read ↗

Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.Semantic proximity Read ↗

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.Semantic proximity Read ↗

Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In VivoSemantic proximity Read ↗

Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.