Article

Metadichol, a natural ligand for the expression of Yamanaka reprogramming factors in somatic and primary cancer cell lines

2022-06-28

Abstract excerpt

<title>Abstract</title> <p>The conversion of somatic cells back into induced pluripotent stem cells (iPSCs) or embryonic-like stem cells involves the introduction of four genes commonly called Yamanaka factors: SOX2, OCT4, KLF4, and c-MYC. One drawback is that these genes and the viral vectors used to introduce them into cells have the potential to cause cancer, and these iPSC lines are not clinically useful. Mos...

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Literature Corpus work: ed6c7ff5-abdb-529e-8422-e46825bec18a
DOI: 10.21203/rs.3.rs-1727437/v4

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