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Metadichol as a Coordinated Activator of Core Cellular Machinery. Part I — Powering Up the Powerhouse: Sub-Nanomolar Metadichol Drives Coordinated Upregulation of the Complete Mitochondrial OXPHOS Gene Program in Human PBMCs

2026-06-09

Abstract excerpt

<h4>Background: </h4> Metadichol is a novel nanoemulsion of long-chain saturated alcohols derived from policosanol that has demonstrated pleiotropic biological activity attributed to agonism of the nuclear receptor VDR (vitamin D receptor) and other nuclear receptors. While Metadichol has been reported to modulate immune function, antioxidant pathways, and gene expression, its direct effects on mitochondrial oxida...

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Literature Corpus work: a98a7de2-ed21-5919-91a4-5315130a767e
DOI: 10.20944/preprints202606.0630.v1

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