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Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in <i>Vibrio cholerae</i> and Downregulate the Expression of Virulence Genes

2016-07-28

Abstract excerpt

Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen. Poly( N -[3-(dimethylamino)propyl]methacrylamide) ( P1 ) and poly( N -(3-aminopropyl) methacrylamide) ( P2 ), cationic polymers that bind to the surface of V. cholerae, the infectious agent causing cholera disease, can sequester the pathogen into clusters. Upon clustering, V. choler...

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Literature Corpus work
ecf0785a-c769-5035-9a53-617e7936136e
DOI
10.1101/066563
Open publication

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Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in <i>Vibrio cholerae</i> and Downregulate the Expression of Virulence GenesDOI 10.1101/066563
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