Article

Development of a smart pH-responsive nano-polymer drug, 2-methoxy-4-vinylphenol conjugate against the intestinal pathogen, Vibrio cholerae

2022-07-21

Abstract excerpt

V. cholerae causes cholera, an acute diarrhoeal disease. The virulence in V. cholerae is regulated by the quorum-sensing mechanism and response regulator LuxO positively regulates the expression of significant virulence determinants adhesion, biofilm formation, and cholera toxin production. Previous in-silico studies revealed that 2-methoxy-4-vinylphenol could bind to the ATP binding site of LuxO and the complex w...

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Literature Corpus work: ed0e7301-2d55-5c5b-9b80-2a8b14f7eb76
DOI: 10.21203/rs.3.rs-1823967/v1

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