Article

STITCH links cellular morphology and gene expression in spatial transcriptomics

2026-06-11

Abstract excerpt

In situ spatial (ISS) sequencing can uncover co-variation between cellular morphology and gene expression in vivo. However, a principled and interpretable mathematical representation of morphology has not yet been applied in this context. In particular, current deep learning-based representations of cell images confound a cell’s shape with its size. We present an interpretable representation of cellular boundary c...

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Literature Corpus work: ecccc092-4f38-5624-8fb3-41ef41122835
DOI: 10.64898/2026.06.07.730714

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