Article

Reconstruction of 3-dimensional tissue organization at the single-cell resolution

2023-01-04

Abstract excerpt

Recent advances in spatial transcriptomics (ST) have allowed for the mapping of tissue heterogeneity, but this technique lacks the resolution to investigate gene expression patterns, cell-cell communications and tissue organization at the single-cell resolution. ST data contains a mixed transcriptome from multiple heterogeneous cells, and current methods predict two-dimensional (2D) coordinates for individual cell...

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Literature Corpus work: 00a58d75-c3bf-53ea-995a-69e8ff341a5d
DOI: 10.1101/2023.01.04.522502

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