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Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway

8 Jul 2025

Abstract excerpt

Objective The purpose of the study is to investigate therapeutic effects of metformin on improving PCOS and the underlying mechanism.Methods PCOS modeling and metformin treatment in rats was performed by subcutaneous injection of dehydroepiandrosterone (DHEA) daily, high-fat diet feeding, and intragastric administration of metformin for 21 consecutive days. PCOS modeling and metformin treatment in KGN cells was...

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Share to Ovarian cancer diagnosis and treatment
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PMID: 40625103
DOI: 10.1080/09513590.2025.2528815

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