Article

Acetylation reader BRD4-driven TXNIP transcription enhances NLRP3 inflammasome activation in PCOS

2025-04-21

Abstract excerpt

<title>Abstract</title> <p>Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by the developmental arrest and dysfunction of ovarian granulosa cells (GCs), serving as a major cause of infertility among women of reproductive age. Persistent activation of thioredoxin-interacting protein (TXNIP) due to aberrant histone acetylation modifications of transcription is a potential trigger; however, i...

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Literature Corpus work: 79c0ab56-bb19-58b6-9def-d601fa7baa00
DOI: 10.21203/rs.3.rs-6321751/v1

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