Article
LinearTurboFold: Linear-time global prediction of conserved structures for RNA homologs with applications to SARS-CoV-2.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2021
Li Sizhen, Zhang He, Zhang Liang, Liu Kaibo, Liu Boxiang, Mathews David H, Huang Liang
Abstract excerpt
The constant emergence of COVID-19 variants reduces the effectiveness of existing vaccines and test kits. Therefore, it is critical to identify conserved structures in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes as potential targets for variant-proof diagnostics and therapeutics. However, the algorithms to predict these conserved structures, which simultaneously fold and align multiple...
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