Article

hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties

2022-05-19

Abstract excerpt

Human ether-a-go-go-related gene (hERG) potassium channel is well-known contributor to drug-induced cardiotoxicity and therefore an extremely important target when performing safety assessments of drug candidates. Ligand-based approaches in connection with quantitative structure active relationships (QSAR) analyses have been developed to predict hERG toxicity. Availability of the recent published cryogenic electro...

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Literature Corpus work: ec879b67-8e6a-5d63-93ba-7e8e9705420a
DOI: 10.20944/preprints202205.0255.v1

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