Article

A prostate cancer gastrointestinal transcriptional phenotype may be associated with diminished response to AR-targeted therapy

2024-06-03

Abstract excerpt

<h4>Background</h4> Prostate cancer is a heterogenous disease, but once it becomes metastatic it eventually becomes treatment resistant. One mechanism of resistance to AR-targeting therapy is lineage plasticity, where the tumor undergoes a transformation to an AR-indifferent phenotype, most studied in the context of neuroendocrine prostate cancer (NEPC). However, activation of additional de- or trans-differentiat...

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Literature Corpus work: ec8339a0-6061-599b-b274-ded093c1ca66
DOI: 10.1101/2024.06.02.595931

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