Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2022

Coleman Ilsa M, DeSarkar Navonil, Morrissey Colm, Xin Li, Roudier Martine P, Sayar Erolcan, Li Dapei, Corey Eva, Haffner Michael C, Nelson Peter S

Abstract excerpt

PURPOSE: To determine whether metastatic castration-resistant prostate cancers (mCRPC) partition into molecular phenotypes corresponding to intrinsic differentiation states and ascertain whether these subtypes exhibit specific druggable features and associate with treatment outcomes. EXPERIMENTAL DESIGN: We used RNAseq, digital spatial profiling, and histological assessments from metastatic biopsies and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen Antagonists
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Docetaxel

Share to Phenotype

Share to Prostatic Neoplasms, Castration-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 35552660
DOI: 10.1158/1078-0432.CCR-21-4289
PMCID: PMC9365375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer.PMID 35552660Read ↗

Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate CancerSemantic proximity Read ↗

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancerSemantic proximity Read ↗

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancerSemantic proximity Read ↗

A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasisSemantic proximity Read ↗

Molecular Subtypes of Prostate Cancer.Semantic proximity Read ↗

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilitiesSemantic proximity Read ↗

A novel prostate cancer subtyping classifier based on luminal and basal phenotypes.Semantic proximity Read ↗

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasisSemantic proximity Read ↗

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasisSemantic proximity Read ↗

Molecular decoupling of lineage identity and morphology in aggressive variant prostate cancerSemantic proximity Read ↗

Clinical phenotypes of castration-resistant prostate cancer.Semantic proximity Read ↗

Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.