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Article

A "splicing switch" provides dual layers of regulation of laminin alpha 3 : implications for wound healing and squamous cell carcinoma

2019-01-01

Abstract excerpt

The laminin α3 gene (LAMA3) generates two major isoforms through alternative promoter usage; LAMA3A and LAMA3B. The ratio between these isoforms has been implicated in squamous cell carcinoma (SCC), with an increased LAMA3A:LAMA3B correlating with poor patient survival. Moreover, the proteins produced, laminin α3a and α3b, have been shown to be functionally distinct in terms of their relative abilities to support...

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Literature Corpus work
ebd29c6b-dd87-5f6a-a2ef-4676ee8c887a
DOI
10.17638/03032876
Open publication

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A "splicing switch" provides dual layers of regulation of laminin alpha 3 : implications for wound healing and squamous cell carcinomaDOI 10.17638/03032876
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