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Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling the responses of T-cells, myeloid derived suppressor cells and NK cells

2023-01-03

Abstract excerpt

<title>Abstract</title> <p><italic><bold>Background</bold></italic>: The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. Immune checkpoint blockers (ICBs) limit the tumor’s immune escape yet only for approximately a third of all tumors and, in most cases, for a limited amount of time. S...

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Literature Corpus work
ebc5f0bf-006f-5dfc-8771-0ab09ca38acb
DOI
10.21203/rs.3.rs-2408433/v1
Open publication

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Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling the responses of T-cells, myeloid derived suppressor cells and NK cellsDOI 10.21203/rs.3.rs-2408433/v1
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