Article

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>B-lymphocytes play major adaptive immune roles, producing antibody and driving T-cell responses. However, how immunometabolism networks support B-cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B-cell transcriptional, translational and metabolomic responses...

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Literature Corpus work: eb970144-aa06-580c-aa5f-2088a75b0448
DOI: 10.21203/rs.3.rs-4413958/v1

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Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9DOI 10.21203/rs.3.rs-4413958/v1Read

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