Article
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells.
Apoptosis : an international journal on programmed cell death - 1 Apr 2007
Takai Y, Matikainen T, Jurisicova A, Kim M R, Trbovich A M, Fujita E, Nakagawa T, Lemmers B, Flavell R A, Hakem R, Momoi T, Yuan J, Tilly J L, Perez G I
Abstract excerpt
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death. Because of the mutual interdependence of germ cells and granulosa cells, herein we generated caspase-2 and -3...
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