Article

Seq2Neo: a comprehensive pipeline for cancer neoantigen immunogenicity prediction

2022-09-16

Abstract excerpt

Neoantigens derived from somatic DNA alterations are ideal cancer-specific targets. In recent years, the combination therapy of PD-1/PD-L1 blockers and neoantigen vaccines shows clinical efficacy in original PD-1/PD-L1 blocker non-responders. However, not all somatic DNA mutations can result in immunogenicity in cancer cells, and efficient tools for predicting the immunogenicity of neoepitope are still urgently ne...

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Literature Corpus work: 55b5bb3a-cb6d-52dc-a44c-9cfcd6ed29b7
DOI: 10.1101/2022.09.14.507872

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