Article

Autophagic plasmid expressing SIRT3 and SIRT4 to improve Alzheimer’s disease

2022-06-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Improving mitochondria dysfunction using gene therapy effectively treats Alzheimer’s disease (AD). Meanwhile, the molecular chaperone-mediated autophagy (CMA) mechanism in mammalian cells helps achieve effective and safe gene therapy. <bold>Methods:</bold> We introduced an internal ribosome entry site (IRES) into a plasmid vector co-expressing <italic>Sirtuin</i...

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Literature Corpus work: eb2dd4e7-6039-5042-9241-c0f263c79c79
DOI: 10.21203/rs.3.rs-1717742/v1

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