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Article

SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.

Biochemical pharmacology - 1 May 2024

Zhang Lijun, Dai Zhenning, Shi Shanshan, Yan Zi, Yang Jiaxin, Xue Wanting, He Yunhao, Mi Siqi, Cheng Cheng, Wang Liangxu, Li Nanxiang, Tan Wei, Jiang Zhenyou, Sun Hanxiao, Li Shiyu

Abstract excerpt

Tumor cells with damaged mitochondria undergo metabolic reprogramming, but gene therapy targeting mitochondria has not been comprehensively reported. In this study, plasmids targeting the normal hepatocyte cell line (L-O2) and hepatocellular carcinoma cell line were generated using three genes SIRT3, SIRT4, and SIRT5. These deacetylases play a variety of regulatory roles in cancer and are related to mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38548246
DOI: 10.1016/j.bcp.2024.116168

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