Article

The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis

2023-05-22

Abstract excerpt

<h4>Background: </h4> Synovial hypoxia is a crucial pathological characteristic of rheumatoid arthritis (RA) that significantly contributes to synovitis and synovial hyperplasia. Fibroblast-like synoviocytes (FLS) respond to hypoxic conditions by undergoing adaptive changes that involve the modulation of gene expression, with hypoxia inducible factors (HIF) playing a pivotal role. The aim of this study was to inve...

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Literature Corpus work: b1a4f3af-92cc-5c77-a2c4-2f6c035019c2
DOI: 10.21203/rs.3.rs-2947807/v1

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