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Article

The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2018

You Sungyong, Koh Jung Hee, Leng Lin, Kim Wan-Uk, Bucala Richard

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by destructive hyperplasia of the synovium. Fibroblast-like synoviocytes (FLS) are a major component of synovial pannus and actively participate in the pathologic progression of RA. How rheumatoid FLS acquire and sustain such a uniquely aggressive phenotype remains poorly understood. We describe the current state of knowledge of the...

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Identifiers

PMID: 29287304
DOI: 10.1002/art.40406
PMCID: PMC5920713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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