Article

Cell-to-cell variations in subcellular localisation of V2R are independent of its expression level

2021-08-09

Abstract excerpt

G protein coupled receptors (GPCRs) translate the actions of hormones into intracellular signalling events. Mutations in GPCRs can prevent their correct expression and trafficking to the cell surface and cause disease. We use single cell measurements in HEK293 cells to show that the balance between endoplasmic reticulum (ER) and cell surface localisation of the Vasopressin 2 receptor (V2R) varies significantly fro...

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Literature Corpus work: eaff23a1-bb80-5a58-aa5e-dd6c83123a62
DOI: 10.1101/2021.08.09.455709

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