Article
Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway.
Traffic (Copenhagen, Denmark) - 1 Dec 2004
Hermosilla Ricardo, Oueslati Morad, Donalies Ute, Schönenberger Eva, Krause Eberhard, Oksche Alexander, Rosenthal Walter, Schülein Ralf
Abstract excerpt
The G protein-coupled V(2) vasopressin receptor is crucially involved in water reabsorption in the renal collecting duct. Mutations in the human V(2) vasopressin receptor gene cause nephrogenic diabetes insipidus. Many of the disease-causing mutants are retained intracellularly by the quality control system of the early secretory pathway. It was previously thought that quality control system is restricted to the...
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