Article

A Case-Based Explainable Graph Neural Network Framework for Mechanistic Drug Repositioning

2025-05-02

Abstract excerpt

Drug repositioning offers a cost-effective alternative to traditional drug development by identifying new uses for existing drugs. Recent advances leverage Graph Neural Networks (GNN) to model complex biological data, showing promise in predicting novel drug-disease associations. However, these frameworks often lack explainability, a critical factor for validating predictions and understanding drug mechanisms. Her...

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Literature Corpus work: eaf45f1b-3edb-598d-be1c-ce303d97bc58
DOI: 10.1101/2025.04.28.651120

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