Article

A Scalable Sign-Aware Multi-Omics Knowledge Graph Foundation Model for Mechanistic Drug Action and Clinical Response Predictions

2026-05-04

Abstract excerpt

Mechanistically predicting drug action requires distinguishing activating from inhibitory interactions across broad chemical space, yet most biomedical knowledge graphs and graph neural networks (GNNs) rely on unsigned associations that obscure regulatory logic and have a limited chemical coverage. Here we present SIGMA-KG ( SIG ned M ulti-omics A tlas K nowledge G raph) and FLASH ( F ast L ightweight A rc...

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Literature Corpus work: 94390b3b-3335-5ae3-94e4-05d17a5752a6
DOI: 10.64898/2026.04.29.721775

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