Article

Deep Learning Can Identify Explainable Reasoning Paths of Mechanism of Drug Action for Drug Repurposing from Multilayer Biological Network

2022-02-11

Abstract excerpt

<title>Abstract</title> <p>The discovery and repurposing of drugs require a deep understanding of the mechanism of drug action (MODA). Existing computational methods model these mechanisms with the help of protein-protein interaction (PPI) network. However, the molecular interactions of drugs in the human body are far beyond the PPI network, and the lack of interpretability of these models hinders their practical...

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Literature Corpus work: 323423ea-1c0a-5381-a22a-c9ac863b3730
DOI: 10.21203/rs.3.rs-1269212/v1

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