Article

Discovery of a radiation countermeasure therapeutic for intestinal injury enabled by human organ chips combined with AI

2025-10-07

Abstract excerpt

There is a need for better therapies for acute radiation injury (ARI) of the human intestine as current treatments offer limited efficacy. As the ileum is most sensitive to radiation in patients receiving cancer radiation therapy, we created human Organ Chip microfluidic culture models lined by primary patient-derived ileal epithelial cells interfaced with intestinal microvascular endothelium and exposed them to c...

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Literature Corpus work: eab9b8b5-52e6-597d-bf70-6882a35f6fe1
DOI: 10.1101/2025.10.03.25337298

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