Back to search

Article

<em>Drosophila melanogaster</em> as a Model of Gastrointestinal Radiation Injury Studies: Conserved Mechanisms, Experimental Approaches, and Countermeasure Discovery

2026-08-06

Abstract excerpt

The gastrointestinal tract is a critical system in acute radiation exposure. Severe radiation exposures can deplete epithelial stem and progenitor cells, compromise barrier integrity, alter host-microbe interactions, and drive fluid loss, inflammation, and systemic decline. Mammalian models remain essential for clinical translation, but their cost and complexity constrain sample sizes, statistical power, large-sca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4e74dfcc-217f-5141-8946-0ede753053cb
DOI
10.20944/preprints202608.0415.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<em>Drosophila melanogaster</em> as a Model of Gastrointestinal Radiation Injury Studies: Conserved Mechanisms, Experimental Approaches, and Countermeasure DiscoveryDOI 10.20944/preprints202608.0415.v1
Discovery of a radiation countermeasure therapeutic for intestinal injury enabled by human organ chips combined with AISemantic proximity
MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosisSemantic proximity
MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosisSemantic proximity
Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiationSemantic proximity
LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity
LGR5+ Intestinal Stem Cells Display Sex-Dependent RadiosensitivitySemantic proximity
Acute Impacts of Ionizing Radiation Exposure on the Gastrointestinal Tract and Gut Microbiome in MiceSemantic proximity
Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch SignalsSemantic proximity
PIKfyve Deficiency Exacerbates Radiation-Induced Intestinal ToxicitySemantic proximity
LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity
An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome AxisSemantic proximity
Modulation of radiation-induced intestinal injury by radioprotective agents: a cellular and molecular perspectivesSemantic proximity
Select a neighboring publication to make it the new centre.