Article

Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning Approach

2025-12-12

Abstract excerpt

Due to the late detection, aggressive nature, and paucity of treatment options, pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers worldwide. MicroRNAs (miRNAs) are small non-coding RNAs that function as oncogenes or tumor suppressors. These are highly stable in the blood circulation, hence increasingly recognized as promising biomarkers for early cancer detection. We hypothesize that certain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea9c156d-8b5f-5374-bbaf-f1efa03d677a
DOI: 10.64898/2025.12.09.693279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning ApproachDOI 10.64898/2025.12.09.693279Read

Survival Analysis of Multi-Omics Data Identifies Potential Prognostic Markers of Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as BiomarkersSemantic proximity Read

Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancerSemantic proximity Read

Predictive value of m5C regulatory gene expression in pancreatic adenocarcinomaSemantic proximity Read

Epigenetic Landscape of DNA Methylation in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer.Semantic proximity Read

Leveraging epigenetic alterations in pancreatic ductal adenocarcinoma for clinical applicationsSemantic proximity Read

Molecular characterization and prognostic relevance of m6A regulators in pancreatic adenocarcinomaSemantic proximity Read

Understanding pancreatic cancer genomesSemantic proximity Read

Identifying drug candidates for pancreatic ductal adenocarcinoma based on integrative multiomics analysisSemantic proximity Read

Computing MicroRNA-Gene Interaction Networks in Pan-cancer Using MiRDriverSemantic proximity Read

Identification of DNA methylation‑driven genes by integrative analysis of DNA methylation and transcriptome data in pancreatic adenocarcinomaSemantic proximity Read