PanomiR: A systems biology framework for analysis of multi-pathway targeting by miRNAs

Abstract excerpt

Charting microRNA (miRNA) regulation across pathways is central to characterizing their role in disease. Yet, current methods reveal only individual miRNA-pathway interactions. We have developed a systems biology approach, Pathway networks of miRNA Regulation (PanomiR), that overcomes these limitations to identify miRNA targeting of groups of interacting pathways using gene expression. The approach does not depen...

Topics

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• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Liver Neoplasms
• Lung Neoplasms
• Metabolic Networks and Pathways
• MicroRNAs
• Prostatic Neoplasms
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

ea3c84c6-859f-5101-a8e1-104fa4c20ef2

DOI

10.1101/2022.07.12.499819