Article

Identifying cytokine-release signatures of flow-driven endothelial remodelling in an intracranial aneurysm cell culture model

2026-06-20

Abstract excerpt

Intracranial aneurysm (IA) rupture is catastrophic, yet current models of rupture-risk inadequately capture underlying IA remodelling mechanisms. Endothelial-haemodynamic interactions are central to these processes, but in vitro flow platforms often lack vessel-relevant geometry or long-term perfusion. Here, temporal and spatial endothelial responses to haemodynamic stress were investigated across idealised and p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea189f38-6ff6-5861-96a8-35456aaf8439
DOI: 10.64898/2026.06.18.733289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying cytokine-release signatures of flow-driven endothelial remodelling in an intracranial aneurysm cell culture modelDOI 10.64898/2026.06.18.733289Read

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm ruptureSemantic proximity Read

Effects of Low and High Aneurysmal Wall Shear Stress on Endothelial Cell Behavior: Differences and SimilaritiesSemantic proximity Read

Single-cell RNA analysis reveals the cell atlas of human intracranial aneurysm and rupture-related inflammation featuresSemantic proximity Read

Shear Difference: Flow Type Dictates Endothelial Flow-Responsive Gene Programs in a 3D-Printed in vitro ModelSemantic proximity Read

Bioprinted Human Primary Arteries Recapitulate Inflammatory Activation and Pharmacologic RescueSemantic proximity Read

Vessel-on-Chip model of the microcirculation in Abdominal aortic aneurysmsSemantic proximity Read

Vascular underpinning of COVID-19Semantic proximity Read

Healthy and diseased in vitro models of vascular systemsSemantic proximity Read

Shear-Induced Macrophage Secretome Promotes Endothelial PermeabilitySemantic proximity Read

“Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions”Semantic proximity Read

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.Semantic proximity Read

Immune Cells and Inflammatory mediators cause endothelial dysfunction in a vascular microphysiological systemSemantic proximity Read