Article

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

2018-08-01

Abstract excerpt

Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 or IDH2, respectively) contribute to oncogenesis via production of the metabolite 2-hydroxyglutarate (2HG). Isoform-selective IDH inhibitors suppress 2HG production and induce clinical responses in patients with IDH1- and IDH2-mutant malignancies. Despite the promising activity of IDH inhibitors, the mechanisms that mediate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea10bd39-3860-51ee-a8fe-8df190fed246
DOI: 10.1101/381954

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibitionDOI 10.1101/381954Read

Biological Roles and Therapeutic Applications of IDH2 Mutations in Human CancerSemantic proximity Read

Biological Role and Therapeutic Potential of IDH Mutations in Cancer.Semantic proximity Read

Isocitrate dehydrogenase gene variants in cancer and their clinical significance.Semantic proximity Read

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancerSemantic proximity Read

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical PerspectivesSemantic proximity Read

IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.Semantic proximity Read

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.Semantic proximity Read

Enigmas of IDH mutations in hematology/oncology.Semantic proximity Read

The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors.Semantic proximity Read

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)Semantic proximity Read

Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities.Semantic proximity Read

Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.Semantic proximity Read