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Article

Biological Role and Therapeutic Potential of IDH Mutations in Cancer.

Cancer cell - 13 Aug 2018

Waitkus Matthew S, Diplas Bill H, Yan Hai

Abstract excerpt

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins acquire a neomorphic enzyme activity to produce the putative oncometabolite D-2-hydroxyglutarate, which is thought to block cellular differentiation by competitively inhibiting α-ketoglutarate-dependent dioxygenases involved in histone and...

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IDH2 gene
Glioma
Isocitrate Dehydrogenase
Leukemia, Myeloid, Acute
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TOR Serine-Threonine Kinases

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Identifiers

PMID: 29805076
DOI: 10.1016/j.ccell.2018.04.011
PMCID: PMC6092238

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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