Article

Cosine Similarity Conflates Clinically Distinct Cancer Variants: A Case for Typed-Graph Retrieval in Precision Oncology Decision Support

2026-05-11

Abstract excerpt

Retrieval-augmented generation (RAG) is increasingly applied to clinical decision support in oncology, where treatment selection depends on identifying a patient’s specific somatic variant from an NGS report and matching it to evidence-graded therapy options. The vector retrieval that underlies most RAG systems uses cosine similarity over text embeddings, an architecture optimized for linguistic proximity rather t...

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Literature Corpus work: e9f1944d-5ec6-55ca-af51-5b9c3a3a3186
DOI: 10.64898/2026.05.05.723102

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