Article

OncoGenRAG: Evidence-Grounded Retrieval and BioBERT Classification for Precision Oncology Variant Interpretation

2026-08-22

Abstract excerpt

The increasing use of tumor sequencing has intensified the need for fast, traceable interpretation of genomic variants. General-purpose large language models can produce fluent answers, but unsupported statements, weak provenance, and stale knowledge limit their suitability for clinical genomics. We developed OncoGenRAG, a research framework that combines a parameter-efficiently fine-tuned BioBERT classifier with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8981aafa-1335-59ef-951a-60b75df67067
DOI: 10.64898/2026.08.20.746121

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

OncoGenRAG: Evidence-Grounded Retrieval and BioBERT Classification for Precision Oncology Variant InterpretationDOI 10.64898/2026.08.20.746121Read

Cosine Similarity Conflates Clinically Distinct Cancer Variants: A Case for Typed-Graph Retrieval in Precision Oncology Decision SupportSemantic proximity Read

Variantscape: Large Language Model-Driven Mining of Biomedical Literature for Clinical Interpretation of Cancer VariantsSemantic proximity Read

Evaluating Language Models for Biomedical Fact-Checking: A Benchmark Dataset for Cancer Variant Interpretation VerificationSemantic proximity Read

OncoCITE: Multimodal Multi-Agent Reconstruction of Clinical Oncology Knowledge Bases from Scientific LiteratureSemantic proximity Read

The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancerSemantic proximity Read

The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretationsSemantic proximity Read

Evolution of the open-access CIViC knowledgebase is driven by the needs of the cancer variant interpretation communitySemantic proximity Read

From Text to Translation: Using Language Models to Prioritize Variants for Clinical ReviewSemantic proximity Read

The Precision Medicine Knowledge Base: an online application for collaborative editing, maintenance and sharing of structured clinical-grade cancer mutations interpretationsSemantic proximity Read

CIViCpy: a Python software development and analysis toolkit for the CIViC knowledgebaseSemantic proximity Read

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.Semantic proximity Read

Transforming Semi-structured Variant Assessments into Computable Clinical Assertions: A Pilot Study for AI-Assisted CurationSemantic proximity Read